DAPT is a γ-secretase inhibitor that blocks Notch signaling. As an inhibitor of Notch, DAPT has been used to study autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). As an inhibitor of γ-secretase with IC50 of 0.115 and 0.2 μM for total Aβ and Aβ42 levels, respectively, DAPT may be useful in the study of β-amyloid (Aβ) formation. It is shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures and in brain extract, cerebrospinal fluid and plasma in vivo.
Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the Notch pathway reporter gene, this compound gave IC50 of 500 nM.
OriGen CP-70 CryoPur-DMSO 细胞冻存液 二甲基亚砜 进口USP级 CE认证 CP70￥1
Lifeline LL-0002 VascuLife EnGS Complete Kit 人内皮细胞培养基套装￥1
Anti-Human CD4 PerCP-Cyanine5.5 人CD4抗体￥4,188
Corning 88-571-kit Natural Killer Cell Serum-free Culture Kit II NK细胞活化扩增培养基套装￥0
Cellartis Y50200 MSC Xeno-Free Culture Medium 人间充质干细胞培养基，无外源无需包被￥1
Origen CS250 Freezing Bags vol-max 30-70mL 冻存袋 细胞治疗用药包材￥1