SAG, SMO agonist
产品英文名称：SAG, SMO agonist
SAG is a highly potent agonist of SMO (smoothened). This small molecule compound activates the hedgehog pathway by directly binding to SMO. Note: in the Gli-1 reporter gene assay, SAG acts as an activator at concentrations from approximately 1 nM to 1 uM, but as an inhibitor at concentrations high than 1 uM.
• Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
• Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 5-15 nM.
• This compound is potentially toxic. Handle with extreme care
• For Research Use Only. Not for Use in Humans.
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