R-spondin-1 Fc fusion, human
产品英文名称：R-spondin-1 Fc fusion, human
产品中文名称：人重组R-spondin-1 Fc fusion蛋白
R-spondin-1 Fc fusion, human产品介绍：
R-spondin-1 Fc fusion, human产品英文简述：
R-spondin-1 is a natural enhancer of the canonical WNT pathway. When used together with WNT proteins that activate the beta-catenin pathway, Rspondin- 1 enhances the activity of canonical WNT proteins by binding to LGR5 and LGR4 (refs.) Injection of recombinant R-Spondin-1 into mouse causes activation of the-catenin pathway and proliferation of intestinal crypt cells, which forms the basis for a clinical trial in amelioration of chemotherapy-induced colitis.
This product is the full-length R-Spondin-1 fused at its C-terminus to the Fc domain of human IgG1. This fusion increases the stability of the protein in vitro and in vivo without compromising its biological activity. StemRD’s R-Spondin-1 Fc fusion protein is produced in human 293 cells as a secreted protein and purified by protein A chromatography.
• Purity: Greater than 90% as determined by SDS-PAGE analysis
• Biological Activity: The activity was determined by using a TCF reporter gene assay in cultured
human cells. The EC50 ranges from 5 - 20 ng/ml in the presence of 10ng/mL human WNT-3a. Activity in other assays should be determined by each individual setting.
• For Research Use Only. Not for Use in Human
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