LY364947
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产品英文名称:LY364947
产品中文名称:LY364947
LY364947产品英文简述:
LY364947 is a selective inhibitor of TGF-beta type-I receptor (IC50 59 nM for TGF-beta RI vs. 400 nM for TGF-beta RII). [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole
Ref: Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-μ type I receptor kinase domain. J. Med. Chem. 46 3953, 2003.
• Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
• Biological Activity: In a cell-based assay measuring the activation of a SMAD reporter gene, this compound gives IC50 around 100-200 nM.
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