XAV-939; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-one, is an inhibitor of Tankryases with IC50 of 11 and 4nM for Tankyrase 1 and Tankyrase 2, respectively. It stimulates beta-catenin degradation by stabilizing axin, resulting in the inhibition of the canonical WNT pathway. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. Tankryase inhibitors are potential therapeutics for cancers as deregulated Wnt/b-catenin pathway activity has been implicated in many cancers.
Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 300 nM
OriGen CP-70 CryoPur-DMSO 细胞冻存液 二甲基亚砜 进口USP级 CE认证 CP70￥1
Lifeline LL-0002 VascuLife EnGS Complete Kit 人内皮细胞培养基套装￥1
Anti-Human CD4 PerCP-Cyanine5.5 人CD4抗体￥4,188
Corning 88-571-kit Natural Killer Cell Serum-free Culture Kit II NK细胞活化扩增培养基套装￥0
Cellartis Y50200 MSC Xeno-Free Culture Medium 人间充质干细胞培养基，无外源无需包被￥1
Origen CS250 Freezing Bags vol-max 30-70mL 冻存袋 细胞治疗用药包材￥1