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产品编号:HY-000256

XAV-939 端锚聚合酶抑制剂 2mg WNT家族

XAV-939

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  • 生产厂家: 美国StemRD公司
  • 订购货号:
  • 保存温度: -20℃
  • 规格型号: 2mg
  • 产品编号: HY-000256
  • 产品种类: 细胞培养辅助试剂

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产品英文名称:XAV-939
产品中文名称:XAV-939

 

XAV-939英文简述:
XAV-939; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-one, is an inhibitor of Tankryases with IC50 of 11 and 4nM for Tankyrase 1 and Tankyrase 2, respectively. It stimulates beta-catenin degradation by stabilizing axin, resulting in the inhibition of the canonical WNT pathway. Both tankyrase isoforms interact with a highly conserved domain of axin and stimulate its degradation through the ubiquitin-proteasome pathway. Tankryase inhibitors are potential therapeutics for cancers as deregulated Wnt/b-catenin pathway activity has been implicated in many cancers.

 

Purity: Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
 
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 300 nM
 

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