Fas和Fas配体（FasL）属于TNF超家族，分别是I型和II型跨膜蛋白。FasL与Fas的结合触发携带Fas细胞的凋亡。凋亡机制涉及通过称为FADD的adaptor分子募集pro-caspase 8蛋白酶，随后将酶原处理成活性形式。然后这些活性caspases蛋白酶切割各种细胞底物，导致最终的细胞死亡。sFasR能够通过充当FasL诱发的decoy受体来抑制FasL诱导的细胞凋亡（sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL）。

BioGems人类FAS预包被ELISA（酶联免疫吸附测定）试剂盒是一种固相免疫测定法，专门设计用于测量FAS，其带有FAS特异预包被鼠单克隆抗体的96孔微孔板。它含有NS0表达的重组FAS。检测抗体是FAS特异的生物素化山羊多克隆抗体。该试剂盒是即用型试剂盒，已经过分析验证。

Human FAS Pre-Coated ELISA试剂盒分析

Product Details

Components组份

Reproducibility重复性

Catalog Number : BGK25445

Description

Fas and Fas Ligand (FasL) belong to the TNF superfamily, and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms. These active caspases then cleave various cellular substrates, leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL.

The BioGems Human FAS Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure FAS with a 96-well strip plate that is pre-coated with mouse monoclonal antibody specific for FAS. It contains NS0-expressed recombinant FAS. The detection antibody is a biotinylated goat polyclonal antibody specific for FAS. The kit is analytically validated with ready to use reagents.