LDE225
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产品英文名称:LDE225
产品中文名称:LDE225
LDE225产品英文简述:
LDE225 (NVP-LDE225) is a potent antagonist of SMO (smoothened). This small molecule compound is a hedgehog pathway inhibitor by directly binding to SMO. This molecule has been developed by the Novartis Pharma for clinical application against hedgehog-dependent cancers.
• Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
• Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives IC50 of 15-40 nM.
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