产品英文名称：LDE225
产品中文名称：LDE225

LDE225产品英文简述：
LDE225 (NVP-LDE225) is a potent antagonist of SMO (smoothened). This small molecule compound is a hedgehog pathway inhibitor by directly binding to SMO. This molecule has been developed by the Novartis Pharma for clinical application against hedgehog-dependent cancers.

• Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
• Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives IC50 of 15-40 nM.